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diff --git a/README.rst b/README.rst
index 4c5971d043..e1ea351f84 100644
--- a/README.rst
+++ b/README.rst
@@ -81,7 +81,7 @@ Thanks for using Matrix!
 Synapse Installation
 ====================
 
-Synapse is the reference python/twisted Matrix homeserver implementation.
+Synapse is the reference Python/Twisted Matrix homeserver implementation.
 
 System requirements:
 
@@ -91,12 +91,13 @@ System requirements:
 
 Installing from source
 ----------------------
+
 (Prebuilt packages are available for some platforms - see `Platform-Specific
 Instructions`_.)
 
-Synapse is written in python but some of the libraries it uses are written in
-C. So before we can install synapse itself we need a working C compiler and the
-header files for python C extensions.
+Synapse is written in Python but some of the libraries it uses are written in
+C. So before we can install Synapse itself we need a working C compiler and the
+header files for Python C extensions.
 
 Installing prerequisites on Ubuntu or Debian::
 
@@ -143,21 +144,27 @@ Installing prerequisites on OpenBSD::
     doas pkg_add python libffi py-pip py-setuptools sqlite3 py-virtualenv \
                  libxslt
 
-To install the synapse homeserver run::
+To install the Synapse homeserver run::
 
     virtualenv -p python2.7 ~/.synapse
     source ~/.synapse/bin/activate
     pip install --upgrade pip
     pip install --upgrade setuptools
-    pip install https://github.com/matrix-org/synapse/tarball/master
+    pip install matrix-synapse
 
-This installs synapse, along with the libraries it uses, into a virtual
+This installs Synapse, along with the libraries it uses, into a virtual
 environment under ``~/.synapse``.  Feel free to pick a different directory
 if you prefer.
 
+This Synapse installation can then be later upgraded by using pip again with the
+update flag::
+
+    source ~/.synapse/bin/activate
+    pip install -U matrix-synapse
+
 In case of problems, please see the _`Troubleshooting` section below.
 
-There is an offical synapse image available at 
+There is an offical synapse image available at
 https://hub.docker.com/r/matrixdotorg/synapse/tags/ which can be used with
 the docker-compose file available at `contrib/docker <contrib/docker>`_. Further information on
 this including configuration options is available in the README on
@@ -167,12 +174,7 @@ Alternatively, Andreas Peters (previously Silvio Fricke) has contributed a
 Dockerfile to automate a synapse server in a single Docker image, at
 https://hub.docker.com/r/avhost/docker-matrix/tags/
 
-Also, Martin Giess has created an auto-deployment process with vagrant/ansible,
-tested with VirtualBox/AWS/DigitalOcean - see 
-https://github.com/EMnify/matrix-synapse-auto-deploy
-for details.
-
-Configuring synapse
+Configuring Synapse
 -------------------
 
 Before you can start Synapse, you will need to generate a configuration
@@ -254,26 +256,6 @@ Setting up a TURN server
 For reliable VoIP calls to be routed via this homeserver, you MUST configure
 a TURN server.  See `<docs/turn-howto.rst>`_ for details.
 
-IPv6
-----
-
-As of Synapse 0.19 we finally support IPv6, many thanks to @kyrias and @glyph
-for providing PR #1696.
-
-However, for federation to work on hosts with IPv6 DNS servers you **must**
-be running Twisted 17.1.0 or later - see https://github.com/matrix-org/synapse/issues/1002
-for details.  We can't make Synapse depend on Twisted 17.1 by default
-yet as it will break most older distributions (see https://github.com/matrix-org/synapse/pull/1909)
-so if you are using operating system dependencies you'll have to install your
-own Twisted 17.1 package via pip or backports etc.
-
-If you're running in a virtualenv then pip should have installed the newest
-Twisted automatically, but if your virtualenv is old you will need to manually
-upgrade to a newer Twisted dependency via:
-
-    pip install Twisted>=17.1.0
-
-
 Running Synapse
 ===============
 
@@ -449,8 +431,7 @@ settings require a slightly more difficult installation process.
    using the ``.`` command, rather than ``bash``'s ``source``.
 5) Optionally, use ``pip`` to install ``lxml``, which Synapse needs to parse
    webpages for their titles.
-6) Use ``pip`` to install this repository: ``pip install
-   https://github.com/matrix-org/synapse/tarball/master``
+6) Use ``pip`` to install this repository: ``pip install matrix-synapse``
 7) Optionally, change ``_synapse``'s shell to ``/bin/false`` to reduce the
    chance of a compromised Synapse server being used to take over your box.
 
@@ -464,37 +445,13 @@ https://github.com/NixOS/nixpkgs/blob/master/nixos/modules/services/misc/matrix-
 
 Windows Install
 ---------------
-Synapse can be installed on Cygwin. It requires the following Cygwin packages:
-
-- gcc
-- git
-- libffi-devel
-- openssl (and openssl-devel, python-openssl)
-- python
-- python-setuptools
-
-The content repository requires additional packages and will be unable to process
-uploads without them:
-
-- libjpeg8
-- libjpeg8-devel
-- zlib
-
-If you choose to install Synapse without these packages, you will need to reinstall
-``pillow`` for changes to be applied, e.g. ``pip uninstall pillow`` ``pip install
-pillow --user``
-
-Troubleshooting:
-
-- You may need to upgrade ``setuptools`` to get this to work correctly:
-  ``pip install setuptools --upgrade``.
-- You may encounter errors indicating that ``ffi.h`` is missing, even with
-  ``libffi-devel`` installed. If you do, copy the ``.h`` files:
-  ``cp /usr/lib/libffi-3.0.13/include/*.h /usr/include``
-- You may need to install libsodium from source in order to install PyNacl. If
-  you do, you may need to create a symlink to ``libsodium.a`` so ``ld`` can find
-  it: ``ln -s /usr/local/lib/libsodium.a /usr/lib/libsodium.a``
 
+If you wish to run or develop Synapse on Windows, the Windows Subsystem For
+Linux provides a Linux environment on Windows 10 which is capable of using the
+Debian, Fedora, or source installation methods. More information about WSL can
+be found at https://docs.microsoft.com/en-us/windows/wsl/install-win10 for
+Windows 10 and https://docs.microsoft.com/en-us/windows/wsl/install-on-server
+for Windows Server.
 
 Troubleshooting
 ===============
@@ -502,7 +459,7 @@ Troubleshooting
 Troubleshooting Installation
 ----------------------------
 
-Synapse requires pip 1.7 or later, so if your OS provides too old a version you
+Synapse requires pip 8 or later, so if your OS provides too old a version you
 may need to manually upgrade it::
 
     sudo pip install --upgrade pip
@@ -537,28 +494,6 @@ failing, e.g.::
 
     pip install twisted
 
-On OS X, if you encounter clang: error: unknown argument: '-mno-fused-madd' you
-will need to export CFLAGS=-Qunused-arguments.
-
-Troubleshooting Running
------------------------
-
-If synapse fails with ``missing "sodium.h"`` crypto errors, you may need
-to manually upgrade PyNaCL, as synapse uses NaCl (https://nacl.cr.yp.to/) for
-encryption and digital signatures.
-Unfortunately PyNACL currently has a few issues
-(https://github.com/pyca/pynacl/issues/53) and
-(https://github.com/pyca/pynacl/issues/79) that mean it may not install
-correctly, causing all tests to fail with errors about missing "sodium.h". To
-fix try re-installing from PyPI or directly from
-(https://github.com/pyca/pynacl)::
-
-    # Install from PyPI
-    pip install --user --upgrade --force pynacl
-
-    # Install from github
-    pip install --user https://github.com/pyca/pynacl/tarball/master
-
 Running out of File Handles
 ~~~~~~~~~~~~~~~~~~~~~~~~~~~
 
@@ -747,6 +682,18 @@ so an example nginx configuration might look like::
       }
   }
 
+and an example apache configuration may look like::
+
+    <VirtualHost *:443>
+        SSLEngine on
+        ServerName matrix.example.com;
+
+        <Location /_matrix>
+            ProxyPass http://127.0.0.1:8008/_matrix nocanon
+            ProxyPassReverse http://127.0.0.1:8008/_matrix
+        </Location>
+    </VirtualHost>
+
 You will also want to set ``bind_addresses: ['127.0.0.1']`` and ``x_forwarded: true``
 for port 8008 in ``homeserver.yaml`` to ensure that client IP addresses are
 recorded correctly.
@@ -901,7 +848,7 @@ to install using pip and a virtualenv::
 
     virtualenv -p python2.7 env
     source env/bin/activate
-    python synapse/python_dependencies.py | xargs pip install
+    python -m synapse.python_dependencies | xargs pip install
     pip install lxml mock
 
 This will run a process of downloading and installing all the needed
@@ -956,5 +903,13 @@ variable.  The default is 0.5, which can be decreased to reduce RAM usage
 in memory constrained enviroments, or increased if performance starts to
 degrade.
 
+Using `libjemalloc <http://jemalloc.net/>`_ can also yield a significant
+improvement in overall amount, and especially in terms of giving back RAM
+to the OS. To use it, the library must simply be put in the LD_PRELOAD
+environment variable when launching Synapse. On Debian, this can be done
+by installing the ``libjemalloc1`` package and adding this line to
+``/etc/default/matrix-synapse``::
+
+    LD_PRELOAD=/usr/lib/x86_64-linux-gnu/libjemalloc.so.1
 
 .. _`key_management`: https://matrix.org/docs/spec/server_server/unstable.html#retrieving-server-keys