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diff --git a/CHANGES.md b/CHANGES.md
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+++ b/CHANGES.md
@@ -1,9 +1,61 @@
+Synapse 1.45.0 (2021-10-19)
+===========================
+
+No functional changes since Synapse 1.45.0rc2.
+
+Known Issues
+------------
+
+- A suspected [performance regression](https://github.com/matrix-org/synapse/issues/11049) which was first reported after the release of 1.44.0 remains unresolved.
+
+  We have not been able to identify a probable cause. Affected users report that setting up a federation sender worker appears to alleviate symptoms of the regression.
+
+Improved Documentation
+----------------------
+
+- Reword changelog to clarify concerns about a suspected performance regression in 1.44.0. ([\#11117](https://github.com/matrix-org/synapse/issues/11117))
+
+
+Synapse 1.45.0rc2 (2021-10-14)
+==============================
+
+This release candidate [fixes](https://github.com/matrix-org/synapse/issues/11053) a user directory [bug](https://github.com/matrix-org/synapse/issues/11025) present in 1.45.0rc1.
+
+Known Issues
+------------
+
+- A suspected [performance regression](https://github.com/matrix-org/synapse/issues/11049) which was first reported after the release of 1.44.0 remains unresolved.
+
+  We have not been able to identify a probable cause. Affected users report that setting up a federation sender worker appears to alleviate symptoms of the regression.
+
+Bugfixes
+--------
+
+- Fix a long-standing bug when using multiple event persister workers where events were not correctly sent down `/sync` due to a race. ([\#11045](https://github.com/matrix-org/synapse/issues/11045))
+- Fix a bug introduced in Synapse 1.45.0rc1 where the user directory would stop updating if it processed an event from a
+  user not in the `users` table. ([\#11053](https://github.com/matrix-org/synapse/issues/11053))
+- Fix a bug introduced in Synapse 1.44.0 when logging errors during oEmbed processing. ([\#11061](https://github.com/matrix-org/synapse/issues/11061))
+
+
+Internal Changes
+----------------
+
+- Add an 'approximate difference' method to `StateFilter`. ([\#10825](https://github.com/matrix-org/synapse/issues/10825))
+- Fix inconsistent behavior of `get_last_client_by_ip` when reporting data that has not been stored in the database yet. ([\#10970](https://github.com/matrix-org/synapse/issues/10970))
+- Fix a bug introduced in Synapse 1.21.0 that causes opentracing and Prometheus metrics for replication requests to be measured incorrectly. ([\#10996](https://github.com/matrix-org/synapse/issues/10996))
+- Ensure that cache config tests do not share state. ([\#11036](https://github.com/matrix-org/synapse/issues/11036))
+
+
 Synapse 1.45.0rc1 (2021-10-12)
 ==============================
 
-**Note:** We are aware of [a performance issue](https://github.com/matrix-org/synapse/issues/11049) introduced in Synapse v1.44.0, as well as [a bug](https://github.com/matrix-org/synapse/issues/11025) with the user directory when using application services. While this release candidate doesn't fix either of those issues, a second release candidate is expected to come out in a few days to address them.
+**Note:** Media storage providers module that read from Synapse's configuration need changes as of this version, see the [upgrade notes](https://matrix-org.github.io/synapse/develop/upgrade#upgrading-to-v1450) for more information.
+
+Known Issues
+------------
 
-Media storage providers module that read from Synapse's configuration need changes as of this version, see the [upgrade notes](https://matrix-org.github.io/synapse/develop/upgrade#upgrading-to-v1450) for more information.
+- We are investigating [a performance issue](https://github.com/matrix-org/synapse/issues/11049) which was reported after the release of 1.44.0.
+- We are aware of [a bug](https://github.com/matrix-org/synapse/issues/11025) with the user directory when using application services. A second release candidate is expected which will resolve this.
 
 Features
 --------